Aminophylline - Hameln Pharma Ltd

Hameln Pharmaceuticals

Description

Aminophylline is used to widen the bronchi and reduce the amount of swelling and mucous in the lungs.

Slow intravenous injection
Severe acute asthma or acute exacerbation of COPD in patients not previously treated with theophylline, by slow intravenous injection over at least 20 minutes (with close monitoring):
• Child: 5 mg/kg (maximum per dose 500 mg), to be followed by intravenous infusion
• Adult: 250–500 mg (maximum per dose 5 mg/kg), to be followed by intravenous infusion.

Severe acute exacerbation of COPD in patients not previously treated with theophylline
• Adult: 250–500 mg (maximum per dose 5 mg/kg), to be followed by intravenous infusion.

By intravenous infusion
Severe acute asthma:
• Child under 12 years: 1 mg/kg/hour, adjusted according to plasma-theophylline concentration.
• Over 12 years: 500–700 mcg/kg/hour, adjusted according to plasma-theophylline concentration
• Elderly: 300 mcg/kg/hour, adjusted according to plasma–theophylline concentration.

Severe acute exacerbation of COPD by intravenous infusion:
• Adult: 500–700 mcg/kg/hour, adjusted according to plasma-theophylline concentration
• Elderly: 300 mcg/kg/hour, adjusted according to plasma-theophylline concentration.

By mouth using modified-release medicines
Chronic asthma:
• Child (body weight 40kg and above): 225 mg twice daily for 1 week, then increased if necessary to 450 mg twice daily, adjusted according to plasma-theophylline concentration.

Reversible airway obstruction:
• Adult (body weight 40kg and above): Initially 225 mg twice daily for 1 week, then increased if necessary to 450 mg twice daily, adjusted according to plasma theophylline concentration.